Human LXR alpha (NR1H3) activation kit by CRISPRa

CAT#: GA106819

NR1H3 CRISPRa kit - CRISPR gene activation of human nuclear receptor subfamily 1 group H member 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NR1H3
• Locus ID: 10062
• Kit Components:

  GA106819G1, NR1H3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106819G2, NR1H3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106819G3, NR1H3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001130101, NM_001130102, NM_001251934, NM_001251935, NM_005693, NM_001363595
• Synonyms: LXR-a; LXRA; RLD-1
• Summary: The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]