Human RRAGB activation kit by CRISPRa

CAT#: GA107037

RRAGB CRISPRa kit - CRISPR gene activation of human Ras related GTP binding B

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RRAGB
• Locus ID: 10325
• Kit Components:

  GA107037G1, RRAGB gRNA vector 1 in pCas-Guide-CRISPRa

  GA107037G2, RRAGB gRNA vector 2 in pCas-Guide-CRISPRa

  GA107037G3, RRAGB gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_006064, NM_016656, NM_001354011, NM_001354013, NR_148683, NR_148684, NR_148685, NR_148686, NR_148687, NR_148688, NR_148689, NR_148690, NR_148691, NR_148692
• Synonyms: bA465E19.1; RAGB
• Summary: Ras-homologous GTPases constitute a large family of signal transducers that alternate between an activated, GTP-binding state and an inactivated, GDP-binding state. These proteins represent cellular switches that are operated by GTP-exchange factors and factors that stimulate their intrinsic GTPase activity. All GTPases of the Ras superfamily have in common the presence of six conserved motifs involved in GTP/GDP binding, three of which are phosphate-/magnesium-binding sites (PM1-PM3) and three of which are guanine nucleotide-binding sites (G1-G3). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]