Human TXNL2 (GLRX3) activation kit by CRISPRa

CAT#: GA107203

GLRX3 CRISPRa kit - CRISPR gene activation of human glutaredoxin 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GLRX3
• Locus ID: 10539
• Kit Components:

  GA107203G1, GLRX3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107203G2, GLRX3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107203G3, GLRX3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001199868, NM_001321980, NM_006541
• Synonyms: GLRX4; GRX3; GRX4; PICOT; TXNL2; TXNL3
• Summary: This gene encodes a member of the glutaredoxin family. Glutaredoxins are oxidoreductase enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. The encoded protein may also inhibit apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for cancer. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]