Human TCP1 delta (CCT4) activation kit by CRISPRa

CAT#: GA107234

CCT4 CRISPRa kit - CRISPR gene activation of human chaperonin containing TCP1 subunit 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CCT4
• Locus ID: 10575
• Kit Components:

  GA107234G1, CCT4 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107234G2, CCT4 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107234G3, CCT4 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001256721, NM_006430
• Synonyms: CCT-DELTA; Cctd; SRB
• Summary: The chaperonin containing TCP1 (MIM 186980) complex (CCT), also called the TCP1 ring complex, consists of 2 back-to-back rings, each containing 8 unique but homologous subunits, such as CCT4. CCT assists the folding of newly translated polypeptide substrates through multiple rounds of ATP-driven release and rebinding of partially folded intermediate forms. Substrates of CCT include the cytoskeletal proteins actin (see MIM 102560) and tubulin (see MIM 191130), as well as alpha-transducin (MIM 139330) (Won et al., 1998 [PubMed 9819444]). [supplied by OMIM, Mar 2008]