Human POMT1 activation kit by CRISPRa

CAT#: GA107242

POMT1 CRISPRa kit - CRISPR gene activation of human protein O-mannosyltransferase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: POMT1
• Locus ID: 10585
• Kit Components:

  GA107242G1, POMT1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107242G2, POMT1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107242G3, POMT1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001077365, NM_001077366, NM_001136113, NM_001136114, NM_007171, NM_001353193, NM_001353194, NM_001353195, NM_001353196, NM_001353197, NM_001353198, NM_001353199, NM_001353200, NR_148391, NR_148392, NR_148393, NR_148394, NR_148395, NR_148396, NR_148397, NR_148398, NR_148399, NR_148400
• Synonyms: LGMD2K; MDDGA1; MDDGB1; MDDGC1; RT
• Summary: The protein encoded by this gene is an O-mannosyltransferase that requires interaction with the product of the POMT2 gene for enzymatic function. The encoded protein is found in the membrane of the endoplasmic reticulum. Defects in this gene are a cause of Walker-Warburg syndrome (WWS) and limb-girdle muscular dystrophy type 2K (LGMD2K). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]