POMT1 Human Gene Knockout Kit (CRISPR)

CAT#: KN405277

POMT1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated.

Product Images

Specifications

Product Data

• Format: 2 gRNA vectors, 1 linear donor
• Donor DNA: EF1a-GFP-P2A-Puro
• Symbol: POMT1
• Locus ID: 10585
• Disclaimer: The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_001077365, NM_001077366, NM_001136113, NM_001136114, NM_007171, NM_001353193, NM_001353194, NM_001353195, NM_001353196, NM_001353197, NM_001353198, NM_001353199, NM_001353200, NR_148391, NR_148392, NR_148393, NR_148394, NR_148395, NR_148396, NR_148397, NR_148398, NR_148399, NR_148400
• Synonyms: LGMD2K; MDDGA1; MDDGB1; MDDGC1; RT
• Summary: The protein encoded by this gene is an O-mannosyltransferase that requires interaction with the product of the POMT2 gene for enzymatic function. The encoded protein is found in the membrane of the endoplasmic reticulum. Defects in this gene are a cause of Walker-Warburg syndrome (WWS) and limb-girdle muscular dystrophy type 2K (LGMD2K). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]