Human TXNIP activation kit by CRISPRa

CAT#: GA107279

TXNIP CRISPRa kit - CRISPR gene activation of human thioredoxin interacting protein

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TXNIP
• Locus ID: 10628
• Kit Components:

  GA107279G1, TXNIP gRNA vector 1 in pCas-Guide-CRISPRa

  GA107279G2, TXNIP gRNA vector 2 in pCas-Guide-CRISPRa

  GA107279G3, TXNIP gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001313972, NM_006472
• Synonyms: ARRDC6; EST01027; HHCPA78; THIF; VDUP1
• Summary: This gene encodes a thioredoxin-binding protein that is a member of the alpha arrestin protein family. Thioredoxin is a thiol-oxidoreductase that is a major regulator of cellular redox signaling which protects cells from oxidative stress. This protein inhibits the antioxidative function of thioredoxin resulting in the accumulation of reactive oxygen species and cellular stress. This protein also functions as a regulator of cellular metabolism and of endoplasmic reticulum (ER) stress. This protein may also function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]