Human KDM5B activation kit by CRISPRa

CAT#: GA107375

KDM5B CRISPRa kit - CRISPR gene activation of human lysine demethylase 5B

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: KDM5B
• Locus ID: 10765
• Kit Components:

  GA107375G1, KDM5B gRNA vector 1 in pCas-Guide-CRISPRa

  GA107375G2, KDM5B gRNA vector 2 in pCas-Guide-CRISPRa

  GA107375G3, KDM5B gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_006618, NM_001314042, NM_001347591
• Synonyms: CT31; JARID1B; PLU-1; PLU1; PPP1R98; PUT1; RBBP2H1A
• Summary: This gene encodes a lysine-specific histone demethylase that belongs to the jumonji/ARID domain-containing family of histone demethylases. The encoded protein is capable of demethylating tri-, di- and monomethylated lysine 4 of histone H3. This protein plays a role in the transcriptional repression or certain tumor suppressor genes and is upregulated in certain cancer cells. This protein may also play a role in genome stability and DNA repair. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]