Human AP4S1 activation kit by CRISPRa

CAT#: GA107676

AP4S1 CRISPRa kit - CRISPR gene activation of human adaptor related protein complex 4 subunit sigma 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: AP4S1
• Locus ID: 11154
• Kit Components:

  GA107676G1, AP4S1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107676G2, AP4S1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107676G3, AP4S1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001128126, NM_001254726, NM_001254727, NM_001254728, NM_001254729, NM_007077
• Synonyms: AP47B; CLA20; CLAPS4; CPSQ6; SPG52
• Summary: This gene encodes a member of the adaptor complexes small subunit protein family. These proteins are components of the heterotetrameric adaptor protein complexes, which play important roles in the secretory and endocytic pathways by mediating vesicle formation and sorting of integral membrane proteins. The encoded protein is the small subunit of adaptor protein complex-4, which is associated with both clathrin- and nonclathrin-coated vesicles. Mutations in this gene are associated with spastic quadriplegic cerebral palsy-6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Dec 2011]