Human LZTS1 activation kit by CRISPRa

CAT#: GA107699

LZTS1 CRISPRa kit - CRISPR gene activation of human leucine zipper tumor suppressor 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: LZTS1
• Locus ID: 11178
• Kit Components:

  GA107699G1, LZTS1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107699G2, LZTS1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107699G3, LZTS1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_021020, NM_001362884
• Synonyms: F37; FEZ1
• Summary: This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer. [provided by RefSeq, Nov 2009]