Human RNF139 activation kit by CRISPRa

CAT#: GA107741

RNF139 CRISPRa kit - CRISPR gene activation of human ring finger protein 139

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RNF139
• Locus ID: 11236
• Kit Components:

  GA107741G1, RNF139 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107741G2, RNF139 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107741G3, RNF139 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_007218
• Synonyms: HRCA1; RCA1; TRC8
• Summary: The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP. [provided by RefSeq, Jul 2008]