Human SP140 activation kit by CRISPRa

CAT#: GA107761

SP140 CRISPRa kit - CRISPR gene activation of human SP140 nuclear body protein

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SP140
• Locus ID: 11262
• Kit Components:

  GA107761G1, SP140 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107761G2, SP140 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107761G3, SP140 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001005176, NM_001278451, NM_001278452, NM_001278453, NM_007237
• Synonyms: LYSP100; LYSP100-A; LYSP100-B
• Summary: This gene encodes a member of the SP100 family of proteins, which are share common domains including an N-terminal homogeneously staining region domain followed by a SP100/autoimmune regulator/NucP41/P75/deformed epidermal autoregulatory factor domain, a plant homeobox zinc finger, and a bromodomain. The encoded protein is interferon-inducible and is expressed at high levels in the nuclei of leukocytes. Variants of this gene have been associated with multiple sclerosis, Crohn's disease, and chronic lymphocytic leukemia. Alternative splicing results in multiple variants. [provided by RefSeq, Aug 2016]