Human KLF12 activation kit by CRISPRa

CAT#: GA107773

KLF12 CRISPRa kit - CRISPR gene activation of human Kruppel like factor 12

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: KLF12
• Locus ID: 11278
• Kit Components:

  GA107773G1, KLF12 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107773G2, KLF12 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107773G3, KLF12 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_007249, NM_016285
• Synonyms: AP-2rep; AP2REP; HSPC122
• Summary: Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]