Human TFEC activation kit by CRISPRa

CAT#: GA107817

TFEC CRISPRa kit - CRISPR gene activation of human transcription factor EC

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TFEC
• Locus ID: 22797
• Kit Components:

  GA107817G1, TFEC gRNA vector 1 in pCas-Guide-CRISPRa

  GA107817G2, TFEC gRNA vector 2 in pCas-Guide-CRISPRa

  GA107817G3, TFEC gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001018058, NM_001244583, NM_012252
• Synonyms: bHLHe34; hTFEC-L; TCFEC; TFE-C; TFEC-L; TFECL
• Summary: This gene encodes a member of the micropthalmia (MiT) family of basic helix-loop-helix leucine zipper transcription factors. MiT transcription factors regulate the expression of target genes by binding to E-box recognition sequences as homo- or heterodimers, and play roles in multiple cellular processes including survival, growth and differentiation. The encoded protein is a transcriptional activator of the nonmuscle myosin II heavy chain-A gene, and may also co-regulate target genes in osteoclasts as a heterodimer with micropthalmia-associated transcription factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]