Human CARD8 activation kit by CRISPRa

CAT#: GA107895

CARD8 CRISPRa kit - CRISPR gene activation of human caspase recruitment domain family member 8

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CARD8
• Locus ID: 22900
• Kit Components:

  GA107895G1, CARD8 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107895G2, CARD8 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107895G3, CARD8 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001184900, NM_001184901, NM_001184902, NM_001184903, NM_001184904, NM_014959, NR_033678, NR_033679, NR_033680, NM_001351782, NM_001351783, NM_001351784, NM_001351786, NM_001351787, NM_001351788, NM_001351789, NM_001351790, NM_001351791, NM_001351792, NR_147707, NM_001365950
• Synonyms: CARDINAL; DACAR; DAKAR; NDPP; NDPP1; TUCAN
• Summary: The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]