Human DKK1 activation kit by CRISPRa

CAT#: GA107930

DKK1 CRISPRa kit - CRISPR gene activation of human dickkopf WNT signaling pathway inhibitor 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DKK1
• Locus ID: 22943
• Kit Components:

  GA107930G1, DKK1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107930G2, DKK1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107930G3, DKK1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_012242
• Synonyms: DKK-1; SK
• Summary: This gene encodes a member of the dickkopf family of proteins. Members of this family are secreted proteins characterized by two cysteine-rich domains that mediate protein-protein interactions. The encoded protein binds to the LRP6 co-receptor and inhibits beta-catenin-dependent Wnt signaling. This gene plays a role in embryonic development and may be important in bone formation in adults. Elevated expression of this gene has been observed in numerous human cancers and this protein may promote proliferation, invasion and growth in cancer cell lines. [provided by RefSeq, Sep 2017]