Human Lipin 1 (LPIN1) activation kit by CRISPRa

CAT#: GA108097

LPIN1 CRISPRa kit - CRISPR gene activation of human lipin 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: LPIN1
• Locus ID: 23175
• Kit Components:

  GA108097G1, LPIN1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108097G2, LPIN1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108097G3, LPIN1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001261427, NM_001261428, NM_001261429, NM_145693, NM_001349199, NM_001349200, NM_001349201, NM_001349202, NM_001349203, NM_001349204, NM_001349205, NM_001349206, NM_001349207, NM_001349208, NR_146080
• Synonyms: PAP1
• Summary: This gene encodes a magnesium-ion-dependent phosphatidic acid phosphohydrolase enzyme that catalyzes the penultimate step in triglyceride synthesis including the dephosphorylation of phosphatidic acid to yield diacylglycerol. Expression of this gene is required for adipocyte differentiation and it also functions as a nuclear transcriptional coactivator with some peroxisome proliferator-activated receptors to modulate expression of other genes involved in lipid metabolism. Mutations in this gene are associated with metabolic syndrome, type 2 diabetes, acute recurrent rhabdomyolysis, and autosomal recessive acute recurrent myoglobinuria (ARARM). This gene is also a candidate for several human lipodystrophy syndromes. [provided by RefSeq, Mar 2017]