Human PHLPP (PHLPP1) activation kit by CRISPRa

CAT#: GA108152

PHLPP1 CRISPRa kit - CRISPR gene activation of human PH domain and leucine rich repeat protein phosphatase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PHLPP1
• Locus ID: 23239
• Kit Components:

  GA108152G1, PHLPP1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108152G2, PHLPP1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108152G3, PHLPP1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_194449
• Synonyms: PHLPP; PLEKHE1; PPM3A; SCOP
• Summary: This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling. [provided by RefSeq, Dec 2011]