Human SLC39A14 activation kit by CRISPRa

CAT#: GA108360

SLC39A14 CRISPRa kit - CRISPR gene activation of human solute carrier family 39 member 14

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SLC39A14
• Locus ID: 23516
• Kit Components:

  GA108360G1, SLC39A14 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108360G2, SLC39A14 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108360G3, SLC39A14 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001128431, NM_001135153, NM_001135154, NM_015359, NM_001351655, NM_001351656, NM_001351657, NM_001351658, NM_001351659, NM_001351660
• Synonyms: cig19; HMNDYT2; LZT-Hs4; NET34; ZIP14
• Summary: This gene encodes a member of the the SLC39A family of divalent metal transporters that mediates the cellular uptake of manganese, zinc, iron, and cadmium. The encoded protein contains eight transmembrane domains, a histidine-rich motif, and a metalloprotease motif, and is expressed on the plasma membrane and the endocytic vesicle membrane. It is an important transporter of nontransferrin-bound iron and a critical regulator of manganese homeostasis. Naturally occurring mutations in this gene are associated with neurodegeneration with brain iron accumulation and early-onset parkinsonism-dystonia with hypermanganesemia. [provided by RefSeq, May 2017]