Human PRAME activation kit by CRISPRa

CAT#: GA108375

PRAME CRISPRa kit - CRISPR gene activation of human preferentially expressed antigen in melanoma

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PRAME
• Locus ID: 23532
• Kit Components:

  GA108375G1, PRAME gRNA vector 1 in pCas-Guide-CRISPRa

  GA108375G2, PRAME gRNA vector 2 in pCas-Guide-CRISPRa

  GA108375G3, PRAME gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001291715, NM_001291716, NM_001291717, NM_001291719, NM_001318126, NM_001318127, NM_006115, NM_206953, NM_206954, NM_206955, NM_206956
• Synonyms: CT130; MAPE; OIP-4; OIP4
• Summary: This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]