PRAME Human Gene Knockout Kit (CRISPR)

CAT#: KN204142BN

PRAME - human gene knockout kit via CRISPR, HDR mediated

Product Images

Specifications

Product Data

• Format: 2 gRNA vectors, 1 GFP-puro donor, 1 scramble control
• Donor DNA: mBFP-Neo
• Symbol: PRAME
• Locus ID: 23532
• Disclaimer: The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_001291715, NM_001291716, NM_001291717, NM_001291719, NM_001318126, NM_001318127, NM_006115, NM_206953, NM_206954, NM_206955, NM_206956
• Synonyms: CT130; MAPE; OIP-4; OIP4
• Summary: This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]