Human AMACR activation kit by CRISPRa

CAT#: GA108427

AMACR CRISPRa kit - CRISPR gene activation of human alpha-methylacyl-CoA racemase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: AMACR
• Locus ID: 23600
• Kit Components:

  GA108427G1, AMACR gRNA vector 1 in pCas-Guide-CRISPRa

  GA108427G2, AMACR gRNA vector 2 in pCas-Guide-CRISPRa

  GA108427G3, AMACR gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001167595, NM_001167596, NM_001167597, NM_001167598, NM_014324, NM_203382
• Synonyms: AMACRD; CBAS4; RACE; RM
• Summary: This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the upstream neighboring C1QTNF3 (C1q and tumor necrosis factor related protein 3) gene. [provided by RefSeq, Mar 2011]