Human CHRDL2 activation kit by CRISPRa

CAT#: GA108604

CHRDL2 CRISPRa kit - CRISPR gene activation of human chordin like 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CHRDL2
• Locus ID: 25884
• Kit Components:

  GA108604G1, CHRDL2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108604G2, CHRDL2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108604G3, CHRDL2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001278473, NM_001304390, NM_001304391, NM_001304415, NM_001304416, NM_001304417, NM_015424
• Synonyms: BNF1; CHL2
• Summary: This gene encodes a member of the chordin family of proteins. Chordin family members are secreted proteins that share a cysteine-rich pro-collagen repeat domain and associate with members of the transforming growth factor beta superfamily. In vitro assays demonstrate a direct interaction between the encoded protein and human activin A. This gene is expressed in many tissues including osteoblasts, where it is differentially expressed during differentiation. In addition, its expression is upregulated in human osteoarthritic joint cartilage, suggesting a role in adult cartilage regeneration. [provided by RefSeq, Jan 2015]