Human ZBTB20 activation kit by CRISPRa

CAT#: GA108769

ZBTB20 CRISPRa kit - CRISPR gene activation of human zinc finger and BTB domain containing 20

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ZBTB20
• Locus ID: 26137
• Kit Components:

  GA108769G1, ZBTB20 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108769G2, ZBTB20 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108769G3, ZBTB20 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001164342, NM_001164343, NM_001164344, NM_001164345, NM_001164346, NM_001164347, NM_015642, NR_121662, NM_001348800, NM_001348801, NM_001348802, NM_001348803, NM_001348804, NM_001348805
• Synonyms: DPZF; HOF; ODA-8S; PRIMS; ZNF288
• Summary: This gene, which was initially designated as dendritic cell-derived BTB/POZ zinc finger (DPZF), belongs to a family of transcription factors with an N-terminal BTB/POZ domain and a C-terminal DNA-bindng zinc finger domain. The BTB/POZ domain is a hydrophobic region of approximately 120 aa which mediates association with other BTB/POZ domain-containing proteins. This gene acts as a transcriptional repressor and plays a role in many processes including neurogenesis, glucose homeostasis, and postnatal growth. Mutations in this gene have been associated with Primrose syndrome as well as the 3q13.31 microdeletion syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2017]