Human PTPN22 activation kit by CRISPRa

CAT#: GA108794

PTPN22 CRISPRa kit - CRISPR gene activation of human protein tyrosine phosphatase non-receptor type 22

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PTPN22
• Locus ID: 26191
• Kit Components:

  GA108794G1, PTPN22 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108794G2, PTPN22 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108794G3, PTPN22 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001193431, NM_001308297, NM_012411, NM_015967
• Synonyms: LYP; LYP1; LYP2; PEP; PTPN8
• Summary: This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Mar 2009]