Human NKIRAS1 activation kit by CRISPRa

CAT#: GA109160

NKIRAS1 CRISPRa kit - CRISPR gene activation of human NFKB inhibitor interacting Ras like 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NKIRAS1
• Locus ID: 28512
• Kit Components:

  GA109160G1, NKIRAS1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA109160G2, NKIRAS1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA109160G3, NKIRAS1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_020345
• Synonyms: kappaB-Ras1; KBRAS1
• Summary: Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB. [UniProtKB/Swiss-Prot Function]