Human Ubiquilin (UBQLN1) activation kit by CRISPRa

CAT#: GA109354

UBQLN1 CRISPRa kit - CRISPR gene activation of human ubiquilin 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: UBQLN1
• Locus ID: 29979
• Kit Components:

  GA109354G1, UBQLN1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA109354G2, UBQLN1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA109354G3, UBQLN1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_013438, NM_053067
• Synonyms: DA41; DSK2; PLIC-1; UBQN; XDRP1
• Summary: This gene encodes an ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and it is found in lesions associated with Alzheimer's and Parkinson's disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]