Human PILRB activation kit by CRISPRa

CAT#: GA109362

PILRB CRISPRa kit - CRISPR gene activation of human paired immunoglobin like type 2 receptor beta

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PILRB
• Locus ID: 29990
• Kit Components:

  GA109362G1, PILRB gRNA vector 1 in pCas-Guide-CRISPRa

  GA109362G2, PILRB gRNA vector 2 in pCas-Guide-CRISPRa

  GA109362G3, PILRB gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_013440, NM_175047, NM_178238
• Synonyms: FDFACT1; FDFACT2
• Summary: The paired immunoglobin-like type 2 receptors consist of highly related activating and inhibitory receptors that are involved in the regulation of many aspects of the immune system. The paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This gene encodes the activating member of the receptor pair and contains a truncated cytoplasmic tail relative to its inhibitory counterpart (PILRA), that has a long cytoplasmic tail with immunoreceptor tyrosine-based inhibitory (ITIM) motifs. This gene is thought to have arisen from a duplication of the inhibitory PILRA gene and evolved to acquire its activating function. [provided by RefSeq, Jun 2013]