Human TFB1M activation kit by CRISPRa

CAT#: GA109570

TFB1M CRISPRa kit - CRISPR gene activation of human transcription factor B1, mitochondrial

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TFB1M
• Locus ID: 51106
• Kit Components:

  GA109570G1, TFB1M gRNA vector 1 in pCas-Guide-CRISPRa

  GA109570G2, TFB1M gRNA vector 2 in pCas-Guide-CRISPRa

  GA109570G3, TFB1M gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_016020, NM_001350501, NM_001350502, NR_146725
• Synonyms: CGI-75; CGI75; mtTFB; mtTFB1
• Summary: The protein encoded by this gene is a dimethyltransferase that methylates the conserved stem loop of mitochondrial 12S rRNA. The encoded protein also is part of the basal mitochondrial transcription complex and is necessary for mitochondrial gene expression. The methylation and transcriptional activities of this protein are independent of one another. Variations in this gene may influence the severity of aminoglycoside-induced deafness (AID). [provided by RefSeq, Aug 2010]