Human RNF12 (RLIM) activation kit by CRISPRa

CAT#: GA109594

RLIM CRISPRa kit - CRISPR gene activation of human ring finger protein, LIM domain interacting

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RLIM
• Locus ID: 51132
• Kit Components:

  GA109594G1, RLIM gRNA vector 1 in pCas-Guide-CRISPRa

  GA109594G2, RLIM gRNA vector 2 in pCas-Guide-CRISPRa

  GA109594G3, RLIM gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_016120, NM_183353
• Synonyms: NY-REN-43; RNF12
• Summary: The protein encoded by this gene is a RING-H2 zinc finger protein. It has been shown to be an E3 ubiquitin protein ligase that targets LIM domain binding 1 (LDB1/CLIM), and causes proteasome-dependent degradation of LDB1. This protein and LDB1 are co-repressors of LHX1/LIM-1, a homeodomain transcription factor. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2009]