Human POLK activation kit by CRISPRa

CAT#: GA109797

POLK CRISPRa kit - CRISPR gene activation of human DNA polymerase kappa

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: POLK
• Locus ID: 51426
• Kit Components:

  GA109797G1, POLK gRNA vector 1 in pCas-Guide-CRISPRa

  GA109797G2, POLK gRNA vector 2 in pCas-Guide-CRISPRa

  GA109797G3, POLK gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_016218, NM_001345921, NM_001345922, NR_144315
• Synonyms: DINB1; DINP; POLQ
• Summary: This gene encodes a member of the DNA polymerase type-Y family of proteins. The encoded protein is a specialized DNA polymerase that catalyzes translesion DNA synthesis, which allows DNA replication in the presence of DNA lesions. Human cell lines lacking a functional copy of this gene exhibit impaired genome integrity and enhanced susceptibility to oxidative damage. Mutations in this gene that impair enzyme activity may be associated with prostate cancer in human patients. [provided by RefSeq, Sep 2016]