Human ACSL5 activation kit by CRISPRa

CAT#: GA109951

ACSL5 CRISPRa kit - CRISPR gene activation of human acyl-CoA synthetase long chain family member 5

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ACSL5
• Locus ID: 51703
• Kit Components:

  GA109951G1, ACSL5 gRNA vector 1 in pCas-Guide-CRISPRa

  GA109951G2, ACSL5 gRNA vector 2 in pCas-Guide-CRISPRa

  GA109951G3, ACSL5 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_016234, NM_203379, NM_203380
• Synonyms: ACS2; ACS5; FACL5
• Summary: The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]