Human CTIP1 (BCL11A) activation kit by CRISPRa

CAT#: GA109998

BCL11A CRISPRa kit - CRISPR gene activation of human BAF chromatin remodeling complex subunit BCL11A

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: BCL11A
• Locus ID: 53335
• Kit Components:

  GA109998G1, BCL11A gRNA vector 1 in pCas-Guide-CRISPRa

  GA109998G2, BCL11A gRNA vector 2 in pCas-Guide-CRISPRa

  GA109998G3, BCL11A gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_018014, NM_022893, NM_138553, NM_138559, NM_001365609, NM_001363864
• Synonyms: BCL11A-L; BCL11a-M; BCL11A-S; BCL11A-XL; CTIP1; DILOS; EVI9; HBFQTL5; ZNF856
• Summary: This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]