Human SLCO1C1 activation kit by CRISPRa

CAT#: GA110042

SLCO1C1 CRISPRa kit - CRISPR gene activation of human solute carrier organic anion transporter family member 1C1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SLCO1C1
• Locus ID: 53919
• Kit Components:

  GA110042G1, SLCO1C1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA110042G2, SLCO1C1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA110042G3, SLCO1C1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001145944, NM_001145945, NM_001145946, NM_017435
• Synonyms: OATP-F; OATP1; OATP1C1; OATP14; OATPF; OATPRP5; SLC21A14
• Summary: This gene encodes a member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of thyroid hormones in brain tissues. This protein has particularly high affinity for the thyroid hormones thyroxine, tri-iodothyronine and reverse tri-iodothyronine. Polymorphisms in the gene encoding this protein may be associated with fatigue and depression in patients suffering from hyperthyroidism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]