Human TREM2 activation kit by CRISPRa

CAT#: GA110075

TREM2 CRISPRa kit - CRISPR gene activation of human triggering receptor expressed on myeloid cells 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TREM2
• Locus ID: 54209
• Kit Components:

  GA110075G1, TREM2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA110075G2, TREM2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA110075G3, TREM2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001271821, NM_018965
• Synonyms: TREM-2; Trem2a; Trem2b; Trem2c
• Summary: This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]