Human ZRANB1 activation kit by CRISPRa

CAT#: GA110250

ZRANB1 CRISPRa kit - CRISPR gene activation of human zinc finger RANBP2-type containing 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ZRANB1
• Locus ID: 54764
• Kit Components:

  GA110250G1, ZRANB1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA110250G2, ZRANB1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA110250G3, ZRANB1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_017580
• Synonyms: TRABID
• Summary: Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling. [UniProtKB/Swiss-Prot Function]