Human THG1L activation kit by CRISPRa

CAT#: GA110419

THG1L CRISPRa kit - CRISPR gene activation of human tRNA-histidine guanylyltransferase 1 like

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: THG1L
• Locus ID: 54974
• Kit Components:

  GA110419G1, THG1L gRNA vector 1 in pCas-Guide-CRISPRa

  GA110419G2, THG1L gRNA vector 2 in pCas-Guide-CRISPRa

  GA110419G3, THG1L gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001317824, NM_001317825, NM_001317826, NM_017872
• Synonyms: hTHG1; ICF45; IHG-1
• Summary: The protein encoded by this gene is a mitochondrial protein that is induced by high levels of glucose and is associated with diabetic nephropathy. The encoded protein appears to increase mitochondrial biogenesis, which could lead to renal fibrosis. Another function of this protein is that of a guanyltransferase, adding GMP to the 5' end of tRNA(His). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]