Human C9orf95 (NMRK1) activation kit by CRISPRa

CAT#: GA110425

NMRK1 CRISPRa kit - CRISPR gene activation of human nicotinamide riboside kinase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NMRK1
• Locus ID: 54981
• Kit Components:

  GA110425G1, NMRK1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA110425G2, NMRK1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA110425G3, NMRK1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001127603, NM_001330678, NM_001330679, NM_017881, NR_023352
• Synonyms: bA235O14.2; C9orf95; NRK1
• Summary: Nicotinamide adenine dinucleotide (NAD+) is essential for life in all organisms, both as a coenzyme for oxidoreductases and as a source of ADP-ribosyl groups used in various reactions. Nicotinic acid and nicotinamide, collectively known as niacin, are the vitamin precursors of NAD+. Nicotinamide riboside kinases, such as NRK1, function to synthesize NAD+ through nicotinamide mononucleotide using nicotinamide riboside as the precursor (Bieganowski and Brenner, 2004 [PubMed 15137942]). [supplied by OMIM, Mar 2008]