Human TRIM68 activation kit by CRISPRa

CAT#: GA110536

TRIM68 CRISPRa kit - CRISPR gene activation of human tripartite motif containing 68

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TRIM68
• Locus ID: 55128
• Kit Components:

  GA110536G1, TRIM68 gRNA vector 1 in pCas-Guide-CRISPRa

  GA110536G2, TRIM68 gRNA vector 2 in pCas-Guide-CRISPRa

  GA110536G3, TRIM68 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001304496, NM_018073
• Synonyms: GC109; RNF137; SS-56; SS56
• Summary: This gene encodes a member of the tripartite motif-containing protein family, whose members are characterized by a "really interesting new gene" (RING) finger domain, a zinc-binding B-box motif, and a coiled-coil region. Members of this family function as E3 ubiquitin ligases and are involved in a broad range of biological processes. This gene regulates the activation of nuclear receptors, such as androgen receptor, and has been implicated in development of prostate cancer cells, where its expression increases in response to a downregulation of microRNAs. In addition, this gene participates in viral defense regulation as a negative regulator of interferon-beta. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]