Human Sulfatase 2 (SULF2) activation kit by CRISPRa

CAT#: GA111071

SULF2 CRISPRa kit - CRISPR gene activation of human sulfatase 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SULF2
• Locus ID: 55959
• Kit Components:

  GA111071G1, SULF2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA111071G2, SULF2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA111071G3, SULF2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001161841, NM_018837, NM_198596
• Synonyms: HSULF-2
• Summary: Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]). [supplied by OMIM, Mar 2008]