Human Signal peptide peptidase like 2B (SPPL2B) activation kit by CRISPRa

CAT#: GA111278

SPPL2B CRISPRa kit - CRISPR gene activation of human signal peptide peptidase like 2B

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SPPL2B
• Locus ID: 56928
• Kit Components:

  GA111278G1, SPPL2B gRNA vector 1 in pCas-Guide-CRISPRa

  GA111278G2, SPPL2B gRNA vector 2 in pCas-Guide-CRISPRa

  GA111278G3, SPPL2B gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001077238, NM_020172, NM_152988
• Synonyms: IMP-4; IMP4; PSH4; PSL1
• Summary: This gene encodes a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]