Human SLC4A10 activation kit by CRISPRa

CAT#: GA111461

SLC4A10 CRISPRa kit - CRISPR gene activation of human solute carrier family 4 member 10

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SLC4A10
• Locus ID: 57282
• Kit Components:

  GA111461G1, SLC4A10 gRNA vector 1 in pCas-Guide-CRISPRa

  GA111461G2, SLC4A10 gRNA vector 2 in pCas-Guide-CRISPRa

  GA111461G3, SLC4A10 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001178015, NM_001178016, NM_022058, NM_001354440, NM_001354441, NM_001354442, NM_001354443, NM_001354444, NM_001354445, NM_001354446, NM_001354447, NM_001354448, NM_001354449, NM_001354450, NM_001354451, NM_001354453, NM_001354455, NM_001354460, NM_001354461
• Synonyms: NBCn2; NCBE
• Summary: This gene belongs to a small family of sodium-coupled bicarbonate transporters (NCBTs) that regulate the intracellular pH of neurons, the secretion of bicarbonate ions across the choroid plexus, and the pH of the brain extracellular fluid. The protein encoded by this gene was initially identified as a sodium-driven chloride bicarbonate exchanger (NCBE) though there is now evidence that its sodium/bicarbonate cotransport activity is independent of any chloride ion countertransport under physiological conditions. This gene is now classified as a member A10 of the SLC4 family of transmembrane solute carriers. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2010]