SLC4A10 Human Gene Knockout Kit (CRISPR)

CAT#: KN416112

SLC4A10 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated.

Product Images

Specifications

Product Data

• Format: 2 gRNA vectors, 1 linear donor
• Donor DNA: EF1a-GFP-P2A-Puro
• Symbol: SLC4A10
• Locus ID: 57282
• Disclaimer: The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_001178015, NM_001178016, NM_022058, NM_001354440, NM_001354441, NM_001354442, NM_001354443, NM_001354444, NM_001354445, NM_001354446, NM_001354447, NM_001354448, NM_001354449, NM_001354450, NM_001354451, NM_001354453, NM_001354455, NM_001354460, NM_001354461
• Synonyms: NBCn2; NCBE
• Summary: This gene belongs to a small family of sodium-coupled bicarbonate transporters (NCBTs) that regulate the intracellular pH of neurons, the secretion of bicarbonate ions across the choroid plexus, and the pH of the brain extracellular fluid. The protein encoded by this gene was initially identified as a sodium-driven chloride bicarbonate exchanger (NCBE) though there is now evidence that its sodium/bicarbonate cotransport activity is independent of any chloride ion countertransport under physiological conditions. This gene is now classified as a member A10 of the SLC4 family of transmembrane solute carriers. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2010]