Human HACE1 activation kit by CRISPRa

CAT#: GA111564

HACE1 CRISPRa kit - CRISPR gene activation of human HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: HACE1
• Locus ID: 57531
• Kit Components:

  GA111564G1, HACE1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA111564G2, HACE1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA111564G3, HACE1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_020771, NR_104424, NM_001321080, NM_001321083, NM_001321084, NM_001350554, NM_001350555, NM_001350556, NM_001350557, NM_001350558, NM_001350559, NM_001350560, NR_146787, NR_146788, NR_146789, NR_146790, NR_146791, NR_146792
• Synonyms: HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1
• Summary: This gene encodes a HECT domain and ankyrin repeat-containing ubiquitin ligase. The encoded protein is involved in specific tagging of target proteins, leading to their subcellular localization or proteasomal degradation. The protein is a potential tumor suppressor and is involved in the pathophysiology of several tumors, including Wilm's tumor. [provided by RefSeq, Mar 2016]