Human Cadherin like 23 (CDH23) activation kit by CRISPRa

CAT#: GA111955

CDH23 CRISPRa kit - CRISPR gene activation of human cadherin related 23

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CDH23
• Locus ID: 64072
• Kit Components:

  GA111955G1, CDH23 gRNA vector 1 in pCas-Guide-CRISPRa

  GA111955G2, CDH23 gRNA vector 2 in pCas-Guide-CRISPRa

  GA111955G3, CDH23 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001171930, NM_001171931, NM_001171932, NM_001171933, NM_001171934, NM_001171935, NM_001171936, NM_022124, NM_052836
• Synonyms: CDHR23; USH1D
• Summary: This gene is a member of the cadherin superfamily, whose genes encode calcium dependent cell-cell adhesion glycoproteins. The encoded protein is thought to be involved in stereocilia organization and hair bundle formation. The gene is located in a region containing the human deafness loci DFNB12 and USH1D. Usher syndrome 1D and nonsyndromic autosomal recessive deafness DFNB12 are caused by allelic mutations of this cadherin-like gene. Upregulation of this gene may also be associated with breast cancer. Alternative splice variants encoding different isoforms have been described. [provided by RefSeq, May 2013]