Human PCDH15 activation kit by CRISPRa

CAT#: GA112246

PCDH15 CRISPRa kit - CRISPR gene activation of human protocadherin related 15

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PCDH15
• Locus ID: 65217
• Kit Components:

  GA112246G1, PCDH15 gRNA vector 1 in pCas-Guide-CRISPRa

  GA112246G2, PCDH15 gRNA vector 2 in pCas-Guide-CRISPRa

  GA112246G3, PCDH15 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001142763, NM_001142764, NM_001142765, NM_001142766, NM_001142767, NM_001142768, NM_001142769, NM_001142770, NM_001142771, NM_001142772, NM_001142773, NM_033056, NM_001354404, NM_001354411, NM_001354420, NM_001354429, NM_001354430
• Synonyms: CDHR15; DFNB23; USH1F
• Summary: This gene is a member of the cadherin superfamily. Family members encode integral membrane proteins that mediate calcium-dependent cell-cell adhesion. It plays an essential role in maintenance of normal retinal and cochlear function. Mutations in this gene result in hearing loss and Usher Syndrome Type IF (USH1F). Extensive alternative splicing resulting in multiple isoforms has been observed in the mouse ortholog. Similar alternatively spliced transcripts are inferred to occur in human, and additional variants are likely to occur. [provided by RefSeq, Dec 2008]