PCDH15 Human Gene Knockout Kit (CRISPR)

CAT#: KN416005

PCDH15 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated.

Product Images

Specifications

Product Data

• Format: 2 gRNA vectors, 1 linear donor
• Donor DNA: EF1a-GFP-P2A-Puro
• Symbol: PCDH15
• Locus ID: 65217
• Disclaimer: The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.

Reference Data

• RefSeq: NM_001142763, NM_001142764, NM_001142765, NM_001142766, NM_001142767, NM_001142768, NM_001142769, NM_001142770, NM_001142771, NM_001142772, NM_001142773, NM_033056, NM_001354404, NM_001354411, NM_001354420, NM_001354429, NM_001354430
• Synonyms: CDHR15; DFNB23; USH1F
• Summary: This gene is a member of the cadherin superfamily. Family members encode integral membrane proteins that mediate calcium-dependent cell-cell adhesion. It plays an essential role in maintenance of normal retinal and cochlear function. Mutations in this gene result in hearing loss and Usher Syndrome Type IF (USH1F). Extensive alternative splicing resulting in multiple isoforms has been observed in the mouse ortholog. Similar alternatively spliced transcripts are inferred to occur in human, and additional variants are likely to occur. [provided by RefSeq, Dec 2008]