Human Livin (BIRC7) activation kit by CRISPRa

CAT#: GA112446

BIRC7 CRISPRa kit - CRISPR gene activation of human baculoviral IAP repeat containing 7

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: BIRC7
• Locus ID: 79444
• Kit Components:

  GA112446G1, BIRC7 gRNA vector 1 in pCas-Guide-CRISPRa

  GA112446G2, BIRC7 gRNA vector 2 in pCas-Guide-CRISPRa

  GA112446G3, BIRC7 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_022161, NM_139317
• Synonyms: KIAP; LIVIN; ML-IAP; MLIAP; RNF50
• Summary: This gene encodes a member of the inhibitor of apoptosis protein (IAP) family, and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Elevated levels of the encoded protein may be associated with cancer progression and play a role in chemotherapy sensitivity. Alternative splicing results in multiple transcript variants [provided by RefSeq, Jul 2013]