Human Sprouty 4 (SPRY4) activation kit by CRISPRa

CAT#: GA113132

SPRY4 CRISPRa kit - CRISPR gene activation of human sprouty RTK signaling antagonist 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SPRY4
• Locus ID: 81848
• Kit Components:

  GA113132G1, SPRY4 gRNA vector 1 in pCas-Guide-CRISPRa

  GA113132G2, SPRY4 gRNA vector 2 in pCas-Guide-CRISPRa

  GA113132G3, SPRY4 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001127496, NM_001293289, NM_001293290, NM_030964
• Synonyms: HH17
• Summary: This gene encodes a member of a family of cysteine- and proline-rich proteins. The encoded protein is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. Activity of this protein impairs the formation of active GTP-RAS. Nucleotide variation in this gene has been associated with hypogonadotropic hypogonadism 17 with or without anosmia. Alternative splicing results in a multiple transcript variants. [provided by RefSeq, Jun 2014]