Human Rho GTPase activating protein 24 (ARHGAP24) activation kit by CRISPRa

CAT#: GA113184

ARHGAP24 CRISPRa kit - CRISPR gene activation of human Rho GTPase activating protein 24

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ARHGAP24
• Locus ID: 83478
• Kit Components:

  GA113184G1, ARHGAP24 gRNA vector 1 in pCas-Guide-CRISPRa

  GA113184G2, ARHGAP24 gRNA vector 2 in pCas-Guide-CRISPRa

  GA113184G3, ARHGAP24 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001025616, NM_001042669, NM_001287805, NM_031305, NM_001346093
• Synonyms: FILGAP; p73; p73RhoGAP; RC-GAP72; RCGAP72
• Summary: This gene encodes a Rho-GTPase activating protein, which is specific for the small GTPase family member Rac. Binding of the encoded protein by filamin A targets it to sites of membrane protrusion, where it antognizes Rac. This results in suppression of lamellae formation and promotion of retraction to regulate cell polarity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]